Article
An Arabidopsis example of association mapping in structured samples.
PLoS genetics - 19 Jan 2007
Zhao Keyan, Aranzana María José, Kim Sung, Lister Clare, Shindo Chikako, Tang Chunlao, Toomajian Christopher, Zheng Honggang, Dean Caroline, Marjoram Paul, Nordborg Magnus
Abstract excerpt
A potentially serious disadvantage of association mapping is the fact that marker-trait associations may arise from confounding population structure as well as from linkage to causative polymorphisms. Using genome-wide marker data, we have previously demonstrated that the problem can be severe in a global sample of 95 Arabidopsis thaliana accessions, and that established methods for controlling for population...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.