Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recovery kinetics of dual AAV-mediated human otoferlin expression

17 Jun 2024

Abstract excerpt

Deafness-causing deficiencies in otoferlin ( OTOF ) have been addressed preclinically using dual adeno-associated virus (AAV)-based approaches. However, timing of transduction, recombination of mRNA, and protein expression with dual hybrid AAV methods methods have not previously been characterized. Here, we have established an ex vivo assay to determine the kinetics of dual-AAV mediated expression of OTOF in hair...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hearing, Cochlea, Tinnitus, Genetics
Share to RNA regulation and disease
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38952419
DOI: 10.3389/fnmol.2024.1376128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recovery kinetics of dual AAV-mediated human otoferlin expressionPMID 38952419Read ↗

Preclinical evaluation of the efficacy and safety of AAV1-hOTOF in mice and non-human primatesSemantic proximity Read ↗

Dual-AAV delivery of large gene sequences to the inner earSemantic proximity Read ↗

<i>In vivo</i> -directed evolution identifies AAV-WM04 as a next-generation vector for potent and durable hearing restoration in DFNB9Semantic proximity Read ↗

Hearing of Otof-deficient mice restored by trans-splicing of N- and C-terminal otoferlin.Semantic proximity Read ↗

Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related DeafnessSemantic proximity Read ↗

<i>In utero</i> adeno-associated virus (AAV)-mediated gene delivery targeting sensory and supporting cells in the embryonic mouse inner earSemantic proximity Read ↗

Rescue of Hearing by Gene Delivery to Inner-Ear Hair Cells Using Exosome-Associated AAV.Semantic proximity Read ↗

PCDH15 Dual-AAV Gene Therapy for Deafness and Blindness in Usher Syndrome Type 1FSemantic proximity Read ↗

Clinical gene therapy restores hearing: a paradigm shift.Semantic proximity Read ↗

In Vivo Delivery of Recombinant Viruses to the Fetal Murine Cochlea: Transduction Characteristics and Long-Term Effects on Auditory FunctionSemantic proximity Read ↗

Simultaneous gentamicin-mediated damage and Atoh1 overexpression promotes hair cell regeneration in the neonatal mouse utricleSemantic proximity Read ↗

Adeno-associated viral vector administration to the inner ear and phenotype evaluation in a mouse model of hearing loss.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.