Article
Hearing of Otof-deficient mice restored by trans-splicing of N- and C-terminal otoferlin.
Human genetics - 1 Feb 2023
Tang Honghai, Wang Hui, Wang Shengyi, Hu Shao Wei, Lv Jun, Xun Mengzhao, Gao Kaiyu, Wang Fang, Chen Yuxin, Wang Daqi, Wang Wuqing, Li Huawei, Shu Yilai
Abstract excerpt
Mutations to the OTOF gene are among the most common reasons for auditory neuropathy. Although cochlear implants are often effective in restoring sound transduction, there are currently no biological treatments for individuals with variants of OTOF. Previous studies have reported the rescue of hearing in DFNB9 mice using OTOF gene replacement although the efficacy needs improvement. Here, we developed a novel...
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