Article
Clinical gene therapy restores hearing: a paradigm shift.
Trends in molecular medicine - 1 Mar 2026
Han Shuang, Chen Ziting, Wang Daqi, Jiang Luoying, Fan Xintai, Zhong Jiake, Cui Chong, Chen Yuxin, Lv Jun, Zhang Jiajia, Zhao Yu, Shi Dazhi, Lu Wei, Chen Suijun, Jiang Hongqun, Yuan Wei, Wang Qin, Feng GuoDong, Liu Xuezhong, Yuan Huijun, Zeng Fan-Gang, Li Huawei, Chen Zheng-Yi, Shu Yilai
Abstract excerpt
Recent breakthroughs in gene therapy for autosomal recessive deafness 9 (DFNB9) caused by OTOF mutations have transformed treatment paradigms for hereditary hearing loss (HHL). To date, eight clinical trials targeting DFNB9 have been registered in 51 centers across eight countries, demonstrating the rapid progress of gene therapy in auditory medicine. These pioneering studies establish the framework for the...
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