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Article

Rescue of Hearing by Gene Delivery to Inner-Ear Hair Cells Using Exosome-Associated AAV.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Feb 2017

György Bence, Sage Cyrille, Indzhykulian Artur A, Scheffer Deborah I, Brisson Alain R, Tan Sisareuth, Wu Xudong, Volak Adrienn, Mu Dakai, Tamvakologos Panos I, Li Yaqiao, Fitzpatrick Zachary, Ericsson Maria, Breakefield Xandra O, Corey David P, Maguire Casey A

Abstract excerpt

Adeno-associated virus (AAV) is a safe and effective vector for gene therapy for retinal disorders. Gene therapy for hearing disorders is not as advanced, in part because gene delivery to sensory hair cells of the inner ear is inefficient. Although AAV transduces the inner hair cells of the mouse cochlea, outer hair cells remain refractory to transduction. Here, we demonstrate that a vector, exosome-associated...

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Share to Dependovirus
Share to Evoked Potentials, Auditory, Brain Stem

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exosomes

Share to Gene Transfer Techniques

Share to Hair Cells, Auditory, Inner

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Share to Transduction, Genetic

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Source

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Identifiers

PMID: 28082074
DOI: 10.1016/j.ymthe.2016.12.010
PMCID: PMC5368844

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