Mutagenicity of chloro-olefins in the Salmonella/mammalian microsome test. I. Allyl chloride mutagenicity re-examined.

doi:10.1016/0165-1218(85)90109-0

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Article

Mutagenicity of chloro-olefins in the Salmonella/mammalian microsome test. I. Allyl chloride mutagenicity re-examined.

Mutation research - 1 Jan 2000

Neudecker T, Henschler D

Abstract excerpt

Contrary to findings published up to now, allyl chloride, a well known directly acting mutagen for Salmonella typhimurium, is efficiently activated by rat-liver homogenate (S9 mix) under non-standard mutagenicity testing conditions. Its indirect, S9-mediated mutagenic activity is greatly enhanced...

Topics

Allyl Compounds
Animals
Biotransformation
Hydrocarbons, Chlorinated
Male
Microsomes, Liver
Mutation
Rats
Salmonella typhimurium
Time Factors

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