Article
Peroxyacetyl nitrate: measurement of its mutagenic activity using the Salmonella/mammalian microsome reversion assay.
Mutation research - 1 Jan 2000
Kleindienst T E, Shepson P B, Edney E O, Claxton L D
Abstract excerpt
Exposures of Salmonella typhimurium strain TA100 with and without S9 metabolic activation to low ppm levels of pure peroxyacetyl nitrate (PAN) in the gas phase were conducted. Measurements of the gas-phase PAN exposure concentration and the concentration of its decomposition products in surrogate test media led to a measured mutagenic activity of 34 +/- 5 revertants/mumole. The data indicate that PAN is a...
Topics
- Acetates
- Animals
- Biotransformation
- Dose-Response Relationship, Drug
- Male
- Microsomes, Liver
- Mutagenicity Tests
- Mutation
- Peracetic Acid
- Rats
- Salmonella typhimurium