Article
The genotoxic potential of nicotine and its major metabolites.
Mutation research - 1 Oct 1995
Doolittle D J, Winegar R, Lee C K, Caldwell W S, Hayes A W, de Bethizy J D
Abstract excerpt
Nicotine is a naturally occurring alkaloid found primarily in members of the solanaceous plant family, which includes tobacco. Nicotine is rapidly absorbed by humans and then metabolized, primarily by cytochrome P450's. Studies on the genotoxic potential of these metabolites are limited. Nicotine and four of its major metabolites: cotinine, nicotine-N'-oxide, cotinine-N-oxide, and trans-3'-hydroxycotinine were...
Topics
- Animals
- CHO Cells
- Cotinine
- Cricetinae
- Cyclic N-Oxides
- Fluorenes
- Mutagenicity Tests
- Mutagens
- Mutation
- Nicotine
- Salmonella typhimurium
- Sister Chromatid Exchange