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Prognostic potential of CUL3 ligase with differential roles in luminal A and basal type breast cancer tumors

28 Jun 2024

Abstract excerpt

Breast cancer is a prevalent and significant cause of mortality in women, and manifests as six molecular subtypes. Its further histologic classification into non-invasive ductal or lobular carcinoma (DCIS) and invasive carcinoma (ILC or IDC) underscores its heterogeneity. The ubiquitin-proteasome system plays a crucial role in breast cancer, with inhibitors targeting the 26S proteasome showing promise in clinical...

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PMID: 38942922
DOI: 10.1038/s41598-024-65692-z

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