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Schizophrenia-associated somatic copy number variants from 12,834 cases reveal contribution to risk and recurrent, isoform-specific <i>NRXN1</i> disruptions

2022-01-01

Abstract excerpt

While inherited and de novo copy number variants (CNV) have been implicated in the genetic architecture of schizophrenia (SCZ), the contribution of somatic CNVs (sCNVs), present in some but not all cells of the body, remains unknown. Here we explore the role of sCNVs in SCZ by analyzing blood-derived genotype arrays from 12,834 SCZ cases and 11,648 controls. sCNVs were more common in cases (0.91%) than in controls...

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Literature Corpus work
c241c81f-41a0-525b-ad31-5b791be14ef9
DOI
10.1101/2021.12.24.21268385
Open publication

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Schizophrenia-associated somatic copy number variants from 12,834 cases reveal contribution to risk and recurrent, isoform-specific <i>NRXN1</i> disruptionsDOI 10.1101/2021.12.24.21268385
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