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Article

Analyzing the impact of T7L variants overexpression on the metabolic profile of Escherichia coli.

Metabolomics : Official journal of the Metabolomic Society - 28 Jun 2024

Kairamkonda Manikyaprabhu, Saxena Harshi, Gulati Khushboo, Poluri Krishna Mohan

Abstract excerpt

INTRODUCTION: Exploring metabolic changes within host E. coli through an untargeted metabolomic study of T7L variants overexpression to optimize engineered endolysins for clinical/therapeutic use. AIM AND OBJECTIVE: This study aims to assess the impact of overexpressing T7L variants on the metabolic profiles of E. coli. The two variants considered include T7L-H37A, which has enhanced lytic activity compared to...

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PMID: 38941046
DOI: 10.1007/s11306-024-02133-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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