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Article

Differential genomic responses in old vs. young humans despite similar levels of modest muscle damage after resistance loading

11 Nov 2009

Abstract excerpt

Across numerous model systems, aging skeletal muscle demonstrates an impaired regenerative response when exposed to the same stimulus as young muscle. To better understand the impact of aging in a human model, we compared changes to the skeletal muscle transcriptome induced by unaccustomed high-intensity resistance loading (RL) sufficient to cause moderate muscle damage in young (37 yr) vs. older (73 yr) adults....

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PMID: 19903761
DOI: 10.1152/physiolgenomics.00151.2009

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