Article

Age-related changes in human skeletal muscle transcriptome and proteome are more affected by chronic inflammation and physical inactivity than primary aging

2023-12-04

Abstract excerpt

Evaluation of the influence of primary and secondary aging on the manifestation of molecular and cellular hallmarks of aging is a challenging and currently unresolved issue. Our study represents the first demonstration of the distinct role of primary aging and chronic inflammation/physical inactivity – the most important drivers of secondary aging, in the regulation of transcriptomic and proteomic profiles in huma...

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Literature Corpus work: e104c6bc-91f6-51df-9d51-434c57a183ce
DOI: 10.1101/2023.12.01.569524

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