Article

Dynamic proteome profiling uncovers age-related impairments in proteostasis and the protective effects of resistance exercise in human skeletal muscle

2025-10-27

Abstract excerpt

A loss of proteostasis is a primary hallmark of ageing that has emerged from mechanistic studies in model organisms, but little is currently known about changes to proteostasis in the muscle of older humans. We used stable isotope labelling (deuterium oxide; D2O) in vivo, and peptide mass spectrometry of muscle samples to investigate differences in proteome dynamics between the muscle of younger (28 ± 5 y; n=4) an...

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Literature Corpus work: b5863b49-4ba2-5bff-afa8-89e4e4615aa8
DOI: 10.1101/2025.10.27.684531

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