Article
Artificial and Natural Sweeteners Biased T1R2/T1R3 Taste Receptors Transactivate Glycosylated Receptors on Cancer Cells to Induce Epithelial-Mesenchymal Transition of Metastatic Phenotype.
Nutrients - 12 Jun 2024
Skapinker Elizabeth, Aldbai Rashelle, Aucoin Emilyn, Clarke Elizabeth, Clark Mira, Ghokasian Daniella, Kombargi Haley, Abraham Merlin J, Li Yunfan, Bunsick David A, Baghaie Leili, Szewczuk Myron R
Abstract excerpt
Understanding the role of biased taste T1R2/T1R3 G protein-coupled receptors (GPCR) agonists on glycosylated receptor signaling may provide insights into the opposing effects mediated by artificial and natural sweeteners, particularly in cancer and metastasis. Sweetener-taste GPCRs can be activated by several active states involving either biased agonism, functional selectivity, or ligand-directed signaling....
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