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Article

Bidirectional Two-Sample Mendelian Randomization Study of Immunoglobulin G N-Glycosylation and Senescence-Associated Secretory Phenotype.

International journal of molecular sciences - 7 Jun 2024

Wang Haotian, Liu Di, Meng Xiaoni, Sun Wenxin, Li Cancan, Lu Huimin, Zheng Deqiang, Wu Lijuan, Sun Shengzhi, Wang Youxin

Abstract excerpt

Observational studies revealed changes in Immunoglobulin G (IgG) N-glycosylation during the aging process. However, it lacks causal insights and remains unclear in which direction causal relationships exist. The two-sample bidirectional Mendelian randomization (MR) design was adopted to explore causal associations between IgG N-glycans and the senescence-associated secretory phenotype (SASP). Inverse variance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38928043
DOI: 10.3390/ijms25126337
PMCID: PMC11203829

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