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Glycans Are a Novel Biomarker of Chronological and Biological Ages

10 Dec 2013

Abstract excerpt

Fine structural details of glycans attached to the conserved N-glycosylation site significantly not only affect function of individual immunoglobulin G (IgG) molecules but also mediate inflammation at the systemic level. By analyzing IgG glycosylation in 5,117 individuals from four European populations, we have revealed very complex patterns of changes in IgG glycosylation with age. Several IgG glycans (including...

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PMID: 24325898
DOI: 10.1093/gerona/glt190

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