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Latrophilin‐3 as a downstream effector of the androgen receptor induces urothelial tumorigenesis

24 Jun 2024

Abstract excerpt

Emerging evidence indicates that androgen receptor (AR) signaling plays a critical role in the pathogenesis of male-dominant urothelial cancer. Meanwhile, latrophilins (LPHNs), a group of the G-protein-coupled receptor to which a spider venom latrotoxin is known to bind, remain largely uncharacterized in neoplastic diseases. The present study aimed to determine the functional role of LPHN3 (encoded by the ADGRL3...

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PMID: 38925569
DOI: 10.1002/mc.23783

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