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Article

Tobacco smoking exposure-mediated ELAVL1 regulates bladder cancer cell senescence via autophagy activation.

Toxicology - 1 Sept 2025

Pu Qiuyi, Gao Fang, Xiao Yanping, Wu Jiajin, Wang Chao, Mo Xiaoxiao, Zhang Zhengdong, Zheng Rui, Wu Dongmei

Abstract excerpt

Tobacco smoking is a well-established risk factor for bladder cancer, which shows connection to cell senescence in various diseases. However, the regulatory mechanisms linking tobacco smoking exposure to senescence regulation in bladder cancer remain incompletely characterized. In this investigation, we demonstrated that the smoking carcinogen 4-aminobiphenyl (4-ABP) inhibited cell senescence while enhancing...

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Source

Identifiers

PMID: 40378909
DOI: 10.1016/j.tox.2025.154193

Genes

ELAVL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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