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Obstructive Sleep Apnea Syndrome Exacerbates NASH Progression via Selective Autophagy‐Mediated Eepd1 Degradation

25 Jun 2024

Abstract excerpt

Obstructive sleep apnea syndrome (OSAS), characterized by chronic intermittent hypoxia (CIH), is an independent risk factor for aggravating non-alcoholic steatohepatitis (NASH). The prevailing mouse model employed in CIH research is inadequate for the comprehensive exploration of the impact of CIH on NASH development due to reduced food intake observed in CIH-exposed mice, which deviates from human responses. To...

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PMID: 38924647
DOI: 10.1002/advs.202405955

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