Article
Red light-activated depletion of drug-refractory glioblastoma stem cells and chemosensitization of an acquired-resistant mesenchymal phenotype.
Photochemistry and photobiology - 1 Jan 2025
Spring Bryan Q, Watanabe Kohei, Ichikawa Megumi, Mallidi Srivalleesha, Matsudaira Tatsuyuki, Timerman Dmitriy, Swain Joseph W R, Mai Zhiming, Wakimoto Hiroaki, Hasan Tayyaba
Abstract excerpt
Glioblastoma stem cells (GSCs) are potent tumor initiators resistant to radiochemotherapy, and this subpopulation is hypothesized to re-populate the tumor milieu due to selection following conventional therapies. Here, we show that 5-aminolevulinic acid (ALA) treatment-a pro-fluorophore used for fluorescence-guided cancer surgery-leads to elevated levels of fluorophore conversion in patient-derived GSC cultures,...
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