Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diethyldithiocarbamate-ferrous oxide nanoparticles inhibit human and mouse glioblastoma stemness: aldehyde dehydrogenase 1A1 suppression and ferroptosis induction

24 Apr 2024

Abstract excerpt

The development of effective therapy for eradicating glioblastoma stem cells remains a major challenge due to their aggressive growth, chemoresistance and radioresistance which are mainly conferred by aldehyde dehydrogenase (ALDH)1A1. The latter is the main stemness mediator via enhancing signaling pathways of Wnt/β-catenin, phosphatidylinositol 3-kinase/AKT, and hypoxia. Furthermore, ALDH1A1 mediates therapeutic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Extracellular vesicles in disease
Share to Ferroptosis and cancer prognosis
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38720782
DOI: 10.3389/fphar.2024.1363511

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diethyldithiocarbamate-ferrous oxide nanoparticles inhibit human and mouse glioblastoma stemness: aldehyde dehydrogenase 1A1 suppression and ferroptosis inductionPMID 38720782Read ↗

Ferroptosis by nanomaterials: targeting cancer stem cells and overcoming drug resistanceSemantic proximity Read ↗

ALDH1-Mediated Autophagy Sensitizes Glioblastoma Cells to FerroptosisSemantic proximity Read ↗

Heterogeneity of Response to Iron-Based Metallodrugs in Glioblastoma Is Associated with Differences in Chemical Structures and Driven by FAS Expression Dynamics and Transcriptomic SubtypesSemantic proximity Read ↗

Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma.Semantic proximity Read ↗

Curcumin decreases malignant characteristics of glioblastoma stem cells via induction of reactive oxygen speciesSemantic proximity Read ↗

Amplified Ferroptosis and Apoptosis Facilitated by Differentiation Therapy Efficiently Suppress the Progression of OsteosarcomaSemantic proximity Read ↗

Investigation into the Effect and Mechanism of Temozolomide (TMZ) Inducing Ferroptosis to Inhibit Glioma Cell ProliferationSemantic proximity Read ↗

Cytotoxicity, dose-enhancement and radiosensitization of glioblastoma cells with rare earth nanoparticlesSemantic proximity Read ↗

Exploring the role of Disulfidptosis in glioma progression: insights into tumor heterogeneity and therapeutic potential through single-cell RNA sequencingSemantic proximity Read ↗

Glioblastoma Relapses Show Increased Markers of Vulnerability to FerroptosisSemantic proximity Read ↗

Metabolic Vulnerabilities of Temozolomide-Resistant Glioblastoma Cells: Implications for Targeted Therapies and Overcoming ChemoresistanceSemantic proximity Read ↗

Temozolomide (TMZ) Inhibits Glioma Cell Proliferation by Inducing Ferroptosis: Effect and MechanismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.