Article
Characterization of glioma stem cells through multiple stem cell markers and their specific sensitization to double-strand break-inducing agents by pharmacological inhibition of ataxia telangiectasia mutated protein.
Brain pathology (Zurich, Switzerland) - 1 Sept 2012
Raso Alessandro, Vecchio Donatella, Cappelli Enrico, Ropolo Monica, Poggi Alessandro, Nozza Paolo, Biassoni Roberto, Mascelli Samantha, Capra Valeria, Kalfas Fotios, Severi Paolo, Frosina Guido
Abstract excerpt
Previous studies have shown that tumor-driving glioma stem cells (GSC) may promote radio-resistance by constitutive activation of the DNA damage response started by the ataxia telangiectasia mutated (ATM) protein. We have investigated whether GSC may be specifically sensitized to ionizing radiation by inhibiting the DNA damage response. Two grade IV glioma cell lines (BORRU and DR177) were characterized for a...
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