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Article

Association of Rare Genetic Variants and Early-Onset Atrial Fibrillation in Ethnic Minority Individuals.

JAMA cardiology - 1 Jul 2021

Chalazan Brandon, Mol Denise, Darbar Faisal A, Ornelas-Loredo Aylin, Al-Azzam Bahaa, Chen Yining, Tofovic David, Sridhar Arvind, Alzahrani Zain, Ellinor Patrick, Darbar Dawood

Abstract excerpt

Importance: Although rare variants in cardiac ion channels, transcription factors, and myocardial structural proteins are associated with early-onset atrial fibrillation (AF) in White individuals of European descent, it remains unclear whether genetic variation also contributes to the cause of AF in those of minority ethnicity. Objectives: To assess the prevalence of rare and novel pathogenic variants in...

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Identifiers

PMID: 33950154
DOI: 10.1001/jamacardio.2021.0994
PMCID: PMC8100900

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