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Article

Digitized Kinetic Analysis Enhances Genotyping Capacity of CRISPR-Based Biosensing.

ACS nano - 9 Jul 2024

Park Joon Soo, Akarapipad Patarajarin, Chen Fan-En, Shao Fangchi, Mostafa Heba, Hsieh Kuangwen, Wang Tza-Huei

Abstract excerpt

CRISPR/Cas systems have been widely employed for nucleic acid biosensing and have been further advanced for mutation detection by virtue of the sequence specificity of crRNA. However, existing CRISPR-based genotyping methods are limited by the mismatch tolerance of Cas effectors, necessitating a comprehensive screening of crRNAs to effectively distinguish between wild-type and point-mutated sequences. To...

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Identifiers

PMID: 38922290
DOI: 10.1021/acsnano.4c05312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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