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Article

INF2 formin variants linked to human inherited kidney disease reprogram the transcriptome, causing mitotic chaos and cell death.

Cellular and molecular life sciences : CMLS - 25 Jun 2024

Labat-de-Hoz Leticia, Fernández-Martín Laura, Correas Isabel, Alonso Miguel A

Abstract excerpt

Mutations in the human INF2 gene cause autosomal dominant focal segmental glomerulosclerosis (FSGS)-a condition characterized by podocyte loss, scarring, and subsequent kidney degeneration. To understand INF2-linked pathogenicity, we examined the effect of pathogenic INF2 on renal epithelial cell lines and human primary podocytes. Our study revealed an increased incidence of mitotic cells with surplus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38916773
DOI: 10.1007/s00018-024-05323-y
PMCID: PMC11335204

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INF2 formin variants linked to human inherited kidney disease reprogram the transcriptome, causing mitotic chaos and cell death.PMID 38916773Read ↗

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