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Article

Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant.

Journal of translational medicine - 22 Apr 2020

Pachetti Maria, Marini Bruna, Benedetti Francesca, Giudici Fabiola, Mauro Elisabetta, Storici Paola, Masciovecchio Claudio, Angeletti Silvia, Ciccozzi Massimo, Gallo Robert C, Zella Davide, Ippodrino Rudy

Abstract excerpt

BACKGROUND: SARS-CoV-2 is a RNA coronavirus responsible for the pandemic of the Severe Acute Respiratory Syndrome (COVID-19). RNA viruses are characterized by a high mutation rate, up to a million times higher than that of their hosts. Virus mutagenic capability depends upon several factors, including the fidelity of viral enzymes that replicate nucleic acids, as SARS-CoV-2 RNA dependent RNA polymerase (RdRp)....

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Identifiers

PMID: 32321524
DOI: 10.1186/s12967-020-02344-6
PMCID: PMC7174922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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