Article
Multiple Mutations Associated with Emergent Variants Can Be Detected as Low-Frequency Mutations in Early SARS-CoV-2 Pandemic Clinical Samples.
Viruses - 13 Dec 2022
Kimbrel Jeffrey, Moon Joseph, Avila-Herrera Aram, Martí Jose Manuel, Thissen James, Mulakken Nisha, Sandholtz Sarah H, Ferrell Tyshawn, Daum Chris, Hall Sara, Segelke Brent, Arrildt Kathryn T, Messenger Sharon, Wadford Debra A, Jaing Crystal, Allen Jonathan E, Borucki Monica K
Abstract excerpt
Genetic analysis of intra-host viral populations provides unique insight into pre-emergent mutations that may contribute to the genotype of future variants. Clinical samples positive for SARS-CoV-2 collected in California during the first months of the pandemic were sequenced to define the dynamics of mutation emergence as the virus became established in the state. Deep sequencing of 90 nasopharyngeal samples...
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