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Polygenic subtype identified in ACCORD trial displays a favorable type 2 diabetes phenotype in the UKBiobank population.

Human genomics - 22 Jun 2024

Hershberger Courtney, Mariam Arshiya, Pantalone Kevin M, Buse John B, Motsinger-Reif Alison A, Rotroff Daniel M

Abstract excerpt

INTRODUCTION: We previously identified a genetic subtype (C4) of type 2 diabetes (T2D), benefitting from intensive glycemia treatment in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Here, we characterized the population of patients that met the C4 criteria in the UKBiobank cohort. RESEARCH DESIGN AND METHODS: Using our polygenic score (PS), we identified C4 individuals in the UKBiobank...

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Identifiers

PMID: 38909264
DOI: 10.1186/s40246-024-00639-z
PMCID: PMC11193210

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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