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Article

Comparison of caffeine consumption behavior with plasma caffeine levels as exposure measures in drug-target mendelian randomization.

American journal of epidemiology - 2 Dec 2024

Woolf Benjamin, Cronjé Héléne T, Zagkos Loukas, Larsson Susanna C, Gill Dipender, Burgess Stephen

Abstract excerpt

Mendelian randomization is an epidemiologic technique that can explore the potential effect of perturbing a pharmacological target. Plasma caffeine levels can be used as a biomarker to measure the pharmacological effects of caffeine. Alternatively, this can be assessed using a behavioral proxy, such as average number of caffeinated drinks consumed per day. Either variable can be used as the exposure in a...

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Identifiers

PMID: 38904434
DOI: 10.1093/aje/kwae143
PMCID: PMC7616520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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