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Article

Genetic investigation into the broad health implications of caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization.

BMC medicine - 20 Feb 2024

Zagkos Loukas, Cronjé Héléne T, Woolf Benjamin, de La Harpe Roxane, Burgess Stephen, Mantzoros Christos S, Elliott Paul, Yuan Shuai, Larsson Susanna C, Tzoulaki Ioanna, Gill Dipender

Abstract excerpt

BACKGROUND: Caffeine is one of the most utilized drugs in the world, yet its clinical effects are not fully understood. Circulating caffeine levels are influenced by the interplay between consumption behaviour and metabolism. This study aimed to investigate the effects of circulating caffeine levels by considering genetically predicted variation in caffeine metabolism. METHODS: Leveraging genetic variants related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38378567
DOI: 10.1186/s12916-024-03298-y
PMCID: PMC10880284

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