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Article

Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis.

Communications biology - 17 Aug 2022

Ruotsalainen Sanni E, Surakka Ida, Mars Nina, Karjalainen Juha, Kurki Mitja, Kanai Masahiro, Krebs Kristi, Graham Sarah, Mishra Pashupati P, Mishra Binisha H, Sinisalo Juha, Palta Priit, Lehtimäki Terho, Raitakari Olli, Milani Lili, Okada Yukinori, Palotie Aarno, Widen Elisabeth, Daly Mark J, Ripatti Samuli

Abstract excerpt

Cardiovascular diseases are the leading cause of premature death and disability worldwide, with both genetic and environmental determinants. While genome-wide association studies have identified multiple genetic loci associated with cardiovascular diseases, exact genes driving these associations remain mostly uncovered. Due to Finland's population history, many deleterious and high-impact variants are enriched in...

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Identifiers

PMID: 35978133
DOI: 10.1038/s42003-022-03552-0
PMCID: PMC9385630

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