The extracellular vesicle transcriptome provides tissue-specific functional genomic annotation relevant to disease susceptibility in obesity.

doi:10.1016/j.xgen.2025.100925

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Article

The extracellular vesicle transcriptome provides tissue-specific functional genomic annotation relevant to disease susceptibility in obesity.

Cell genomics - 10 Sept 2025

Chatterjee Emeli, Betti Michael J, Sheng Quanhu, Lin Phillip, Emont Margo P, Li Guoping, Amancherla Kaushik, Garcia-Contreras Marta, Gokulnath Priyanka, Limpitikul Worawan B, Whittaker Olivia Rosina, Luong Kathy, Azzam Christopher, Gee Denise, Hutter Matthew, Flanders Karen, Sahu Parul, Flynn Charles R, Brown Jonathan, Yu Danxia, Rosen Evan D, Van-Keuren Jensen Kendall, Gamazon Eric R, Shah Ravi, Das Saumya

Abstract excerpt

We characterized circulating extracellular vesicles (EVs) in obese and lean humans, identifying transcriptional cargo differentially expressed in obesity (277 unique genes; false discovery rate < 10%). Since circulating EVs may have broad origin, we compared this obesity EV transcriptome with expression from human visceral-adipose-tissue-derived EVs from freshly collected and cultured biopsies from the same obese...

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Identifiers

PMID: 40669467
DOI: 10.1016/j.xgen.2025.100925
PMCID: PMC12534702

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