A rare missense variant in the milk fat globule-EGF factor 8 (MFGE8) increases T2DM susceptibility and cardiovascular disease risk with population-specific effects.

doi:10.1007/s00592-019-01463-x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A rare missense variant in the milk fat globule-EGF factor 8 (MFGE8) increases T2DM susceptibility and cardiovascular disease risk with population-specific effects.

Acta diabetologica - 1 Jun 2020

Sapkota Bishwa R, Sanghera Dharambir K

Abstract excerpt

AIMS: The milk fat globule-epidermal growth factor 8 (MFGE8), also called lactadherin, is an integrin ligand and a known mediator of inflammation and atherosclerosis in T2DM in studies using animal models. However, its role in the pathophysiology of human T2DM, obesity, and cardiovascular disease has been poorly explored. Aim of this study was to investigate the role of a missense variant (rs371227978 C/T:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Surface

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiovascular Diseases

Share to Diabetes Mellitus, Type 2

Share to Diabetic Angiopathies

Share to Ethnicity

Share to Exome Sequencing

Share to India

Share to Milk Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 32025861
DOI: 10.1007/s00592-019-01463-x
PMCID: PMC10502938

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A rare missense variant in the milk fat globule-EGF factor 8 (MFGE8) increases T2DM susceptibility and cardiovascular disease risk with population-specific effects.PMID 32025861Read ↗

Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis.Semantic proximity Read ↗

MFGE8 polymorphisms are significantly associated with metabolism-related indicators rather than metabolic syndrome in Chinese people: A nested case-control study.Semantic proximity Read ↗

Association of the single-nucleotide polymorphism in the MFG-E8 gene with coronary heart disease in Chinese Han population.Semantic proximity Read ↗

Loss-of-function of <i>MFGE8</i> and protection against coronary atherosclerosisSemantic proximity Read ↗

Contribution of Circulating Mfge8 to Human T2DM and Cardiovascular DiseaseSemantic proximity Read ↗

Contribution of circulating Mfge8 to human T2DM and cardiovascular disease.Semantic proximity Read ↗

<i>ANGPTL8</i> protein-truncating variant and the risk of coronary disease, type 2 diabetes and adverse effectsSemantic proximity Read ↗

Polymorphisms of MFGE8 are associated with susceptibility and clinical manifestations through gene expression modulation in Koreans with systemic lupus erythematosus.Semantic proximity Read ↗

The Inflammatory Role of Milk Fat Globule Epidermal Growth Factor VIII in Angiotensin II Induced Arterial RemodelingSemantic proximity Read ↗

Association between Serum Milk Fat Globule-EGF Factor 8 and Prognosis in Patients with Heart FailureSemantic proximity Read ↗

Association of circulating lactoferrin concentration and 2 nonsynonymous LTF gene polymorphisms with dyslipidemia in men depends on glucose-tolerance status.Semantic proximity Read ↗

Genome-wide gene–diet interaction analysis in the UK Biobank identifies novel effects on hemoglobin A1cSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.