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Article

Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism

19 Jun 2024

Abstract excerpt

Abstract Viral genetic diversity presents significant challenges in developing antivirals with broad-spectrum activity and high barriers to resistance. Here we report development of proteolysis targeting chimeras (PROTACs) targeting the dengue virus envelope (E) protein through coupling of known E fusion inhibitors to ligands of the CRL4 CRBN E3 ubiquitin ligase. The resulting small molecules block viral entry...

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PMID: 38898037
DOI: 10.1038/s41467-024-49161-9

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