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Production of serine protease inhibitors by mutagenesis and their effects on the mortality of Aedes aegypti L. larvae.

Parasites & vectors - 6 Oct 2015

Soares Tatiane Sanches, Torquato Ricardo José Soares, Gonzalez Yamile Gonzalez, Lemos Francisco Jose Alves, Tanaka Aparecida Sadae

Abstract excerpt

BACKGROUND: Dengue, transmitted primarily by the bites of infected Aedes aegypti L., is transmitted to millions of individuals each year in tropical and subtropical areas. Dengue control strategies are primarily based on controlling the vector, using insecticides, but the appearance of resistance poses new challenges. Recently, highly selective protease inhibitors by phage display were obtained for digestive...

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PMID: 26444542
DOI: 10.1186/s13071-015-1127-4
PMCID: PMC4596559

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