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Article

Measles virus entry inhibitors: a structural proposal for mechanism of action and the development of resistance.

Biochemistry - 23 Dec 2008

Prussia Andrew J, Plemper Richard K, Snyder James P

Abstract excerpt

Previously, we developed a panel of nonpeptidic compounds specifically preventing fusion of the measles virus (MV) with target cells at IC(50) values of 0.6-3 muM. Mutations in the MV fusion protein (MV F) that render resistance to these blockers were described. The structural basis for both inhibition and resistance was unclear in the earlier work because of the availability of a structural model for only the...

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Identifiers

PMID: 19035834
DOI: 10.1021/bi801513p
PMCID: PMC4084900

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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