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Article

PINK1-PARK2-mediated mitophagy in COPD and IPF pathogeneses

12 Jul 2018

Abstract excerpt

Mitochondria regulate not only cell functions through energy generation but also aging-associated cell phenotypes. Impaired mitochondrial structural and functional integrity accompanied by excessive mitochondrial reactive oxygen species (mtROS) production is associated with enhanced programmed cell death (PCD) and cellular senescence. Dysregulation of mechanisms for mitochondrial integrity, including mitophagy,...

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Share to Autophagy in Disease and Therapy
Share to Chronic Obstructive Pulmonary Disease (COPD) Research
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PMID: 30386443
DOI: 10.1186/s41232-018-0077-6

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