Exome Sequencing: the Search for Mutations Associated with Hereditary Breast and Ovarian Cancers in the Tuvan Ethnic Group (A Pilot Study).

doi:10.1007/s10517-024-06112-0

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Article

Exome Sequencing: the Search for Mutations Associated with Hereditary Breast and Ovarian Cancers in the Tuvan Ethnic Group (A Pilot Study).

Bulletin of experimental biology and medicine - 1 Apr 2024

Gervas P, Molokov A, Zarubin A, Shivit-Ool A A, Babyshkina N, Shefer N, Topolnitsky E, Pisareva L, Choinzonov E, Cherdyntseva N

Abstract excerpt

Whole exome sequencing of peripheral blood samples from Tuvan females diagnosed with breast and ovarian cancers (BC/OC) was performed to search for new genes involved in BC/OC pathogenesis. Considering the high cost of whole exome sequencing and study material requirements, 9 samples were selected from 61 genomic DNA samples. A mutation in the LGR4 gene (rs34804482) involved in the tumor-mediated Wnt signaling...

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PMID: 38896321
DOI: 10.1007/s10517-024-06112-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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