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Article

Whole exome sequencing identifies FANCM as a susceptibility gene for estrogen-receptor-negative breast cancer in Hispanic/Latina women.

Nature communications - 21 Aug 2025

Nierenberg Jovia L, Adamson Aaron W, Hu Donglei, Huntsman Scott, Patrick Carmina, Li Min, Steele Linda, Tao Shu, Ding Yuan Chun, Tong Barry, Shieh Yiwey, Fejerman Laura, Gruber Stephen B, Haiman Christopher A, John Esther M, Kushi Lawrence H, Torres-Mejía Gabriela, Ricker Charité, Weitzel Jeffrey N, Ziv Elad, Neuhausen Susan L

Abstract excerpt

Breast cancer (BC) is one of the most common cancers globally. Genetic testing facilitates screening and informs targeted risk-reduction and treatments. However, genes included in testing panels are from European-ancestry studies. We conducted a pooled case-control analysis in self-identified Hispanic/Latina women (4178 cases and 4344 controls), using whole exome sequencing and a targeted panel. We tested the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40841357
DOI: 10.1038/s41467-025-60564-0
PMCID: PMC12370925

Genes

FANCM
BRCA1
BRCA2
PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Whole exome sequencing identifies FANCM as a susceptibility gene for estrogen-receptor-negative breast cancer in Hispanic/Latina women.PMID 40841357Read ↗

Whole exome sequencing and replication for breast cancer among Hispanic/Latino women identifies<i>FANCM</i>as a susceptibility gene for estrogen-receptor-negative breast cancerSemantic proximity Read ↗

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