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Article

New potential therapeutic approaches targeting synovial fibroblasts in rheumatoid arthritis

26 Oct 2021

Abstract excerpt

Synovial cells play a key role in joint destruction during chronic inflammation. In particular, activated synovial fibroblasts (SFs) undergo intrinsic alterations leading to an aggressive phenotype mediating cartilage destruction and bone erosion in rheumatoid arthritis (RA). Recent research has revealed a number of targets to control arthritogenic changes in SFs. Therefore, identification of SF phenotypes,...

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PMID: 34715065
DOI: 10.1016/j.bcp.2021.114815

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