Association of carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis with the HLA-B75 serotype or HLA-B*15:21 allele in Filipino patients.

doi:10.1038/s41397-019-0143-8

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Article

Association of carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis with the HLA-B75 serotype or HLA-B*15:21 allele in Filipino patients.

The pharmacogenomics journal - 1 Jun 2020

Capule Francis, Tragulpiankit Pramote, Mahasirimongkol Surakameth, Jittikoon Jiraphun, Wichukchinda Nuanjun, Theresa Alentajan-Aleta Lara, James Barit Jay-V, Casanova-Gutierrez Josephine, Cabral-Lim Leonor, Baltazar Reyes Jose Paciano, Roa Francisca, Salonga Raymark, San Gabriel Katrina Faith, Lynn Silao Catherine

Abstract excerpt

A case-control study was conducted to investigate the association of HLA-A alleles, HLA-B alleles including HLA-B*15:02 and HLA-B75 serotype with carbamazepine-induced SJS/TEN in Filipino patients. A retrospective review of medical records was performed. Pertinent clinical data were collected. Eight (8) carbamazepine-induced SJS/TEN cases and 32 tolerant controls were recruited. Genomic DNA was extracted from the...

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PMID: 31896765
DOI: 10.1038/s41397-019-0143-8

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