Article
Blood pressure and renal sodium handling in relation to genetic variation in the DRD1 promoter and GRK4.
Hypertension (Dallas, Tex. : 1979) - 1 Jun 2008
Staessen Jan A, Kuznetsova Tatiana, Zhang Haifeng, Maillard Marc, Bochud Murielle, Hasenkamp Sandra, Westerkamp Judith, Richart Tom, Thijs Lutgarde, Li Xinli, Brand-Herrmann Stefan-Martin, Burnier Michel, Brand Eva
Abstract excerpt
Activation of type-1 dopamine receptors (DRD1) reduces renal sodium reabsorption. In a family-based random sample of 611 untreated whites (women, 45.0%; mean age, 38.6 years), we measured blood pressure (BP). We used the endogenous lithium clearance to assess fractional sodium excretion (FE(Na)) and proximal (RNa(prox)) and distal (RNa(dist)) tubular sodium reabsorption. We investigated multivariate-adjusted...
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