Article
Lower prevalence of the OCT2 Ser270 allele in patients with essential hypertension.
Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 Oct 2006
Lazar Andreas, Zimmermann Tim, Koch Werner, Gründemann Dirk, Schömig Albert, Kastrati Adnan, Schömig Edgar
Abstract excerpt
Impairment of the renal dopaminergic pathway has been shown to result in essential hypertension. The Organic Cation Transporter 2, OCT2 (SLC22A2), has been implicated in renal dopamine handling as well as in the inactivation of circulating catecholamines and is supposed to be involved in blood pressure regulation. This study investigated the association of the OCT2 Ala270Ser polymorphism with essential...
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