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A tale of two functions: C-reactive protein complement-ary structures and their role in rheumatoid arthritis

15 Jun 2024

Abstract excerpt

C-reactive protein (CRP) is an inflammatory biomarker with associated clinical utility in a wide number of inflammatory disorders, including rheumatoid arthritis (RA). The interaction of CRP with pro-inflammatory cytokines has been explored before, however its role in complement regulation is more subtle, where CRP is capable of both up and downregulating the complement cascade. CRP is produced in a pentameric...

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PMID: 38885803
DOI: 10.1016/j.clim.2024.110281

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