Article
Proteome-wide association study of prostate cancer risk across populations.
Nature communications - 6 Dec 2025
Zhong Hua, Zhu Jingjing, Liu Shuai, Wu Chong, Wang Liang, Whelton Seamus P, Marshall Catherine H, Blaha Michael J, Durda Peter, Guo Xiuqing, Johnson Craig W, Lin Henry J, Taylor Kent D, Tracy Russell P, Yarden Ronit I, Manichaikul Ani W, Rich Stephen S, Rotter Jerome I, Deo Rajat, Dubin Ruth F, Ganz Peter, Wu Lang
Abstract excerpt
There is insufficient understanding of the molecular basis of prostate cancer (PCa) across different populations. We perform a large-scale proteome-wide association study (PWAS) to identify proteins with genetically regulated expression in plasma to be associated with PCa risk across populations. We develop genetic prediction models for expression of 1578, 1993, 1218, and 1390 proteins for African (n = 450),...
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