Article
Integrated platform for multiscale molecular imaging and phenotyping of the human brain.
Science (New York, N.Y.) - 14 Jun 2024
Park Juhyuk, Wang Ji, Guan Webster, Gjesteby Lars A, Pollack Dylan, Kamentsky Lee, Evans Nicholas B, Stirman Jeff, Gu Xinyi, Zhao Chuanxi, Marx Slayton, Kim Minyoung E, Choi Seo Woo, Snyder Michael, Chavez David, Su-Arcaro Clover, Tian Yuxuan, Park Chang Sin, Zhang Qiangge, Yun Dae Hee, Moukheiber Mira, Feng Guoping, Yang X William, Keene C Dirk, Hof Patrick R, Ghosh Satrajit S, Frosch Matthew P, Brattain Laura J, Chung Kwanghun
Abstract excerpt
Understanding cellular architectures and their connectivity is essential for interrogating system function and dysfunction. However, we lack technologies for mapping the multiscale details of individual cells and their connectivity in the human organ-scale system. We developed a platform that simultaneously extracts spatial, molecular, morphological, and connectivity information of individual cells from the same...
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