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Article

Structural and molecular interrogation of intact biological systems.

Nature - 16 May 2013

Chung Kwanghun, Wallace Jenelle, Kim Sung-Yon, Kalyanasundaram Sandhiya, Andalman Aaron S, Davidson Thomas J, Mirzabekov Julie J, Zalocusky Kelly A, Mattis Joanna, Denisin Aleksandra K, Pak Sally, Bernstein Hannah, Ramakrishnan Charu, Grosenick Logan, Gradinaru Viviana, Deisseroth Karl

Abstract excerpt

Obtaining high-resolution information from a complex system, while maintaining the global perspective needed to understand system function, represents a key challenge in biology. Here we address this challenge with a method (termed CLARITY) for the transformation of intact tissue into a nanoporous hydrogel-hybridized form (crosslinked to a three-dimensional network of hydrophilic polymers) that is fully assembled...

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Identifiers

PMID: 23575631
DOI: 10.1038/nature12107
PMCID: PMC4092167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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