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Type I interferon exacerbates Mycobacterium tuberculosis induced human macrophage death

12 Jun 2024

Abstract excerpt

Type I interferons (IFN-I) are implicated in exacerbation of tuberculosis (TB), but the mechanisms are unclear. Mouse macrophages infected with Mycobacterium tuberculosis (Mtb) produce IFN-I, which contributes to their death. Here we investigate whether the same is true for human monocyte-derived macrophages (MDM). MDM prepared by a conventional method markedly upregulate interferon-stimulated genes (ISGs) upon...

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PMID: 38866980
DOI: 10.1038/s44319-024-00171-0

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