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The identification of high-performing antibodies for Sequestosome-1 for use in Western blot, immunoprecipitation and immunofluorescence

2024-07-10

Abstract excerpt

Sequestosome-1, encoded by the gene SQSTM1 , functions as a bridge between ubiquitinated proteins and the proteasome or autophagosome, thereby regulating protein degradation pathways. Loss of Sequestosome-1 is hypothesized to enhance neurodegeneration progression in several diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal disorders (FTD). Sequestosome-1 reproducible research would be fac...

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Literature Corpus work
20e323c8-bf55-5d84-805b-74187bcb188b
DOI
10.12688/f1000research.132628.2
Open publication

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